Home Research Research Library Documentation of Compounded GLP‐1 Receptor Agonists in a Large Primary Care Dataset Documentation of Compounded GLP‐1 Receptor Agonists in a Large Primary Care Dataset 2025 Author(s) Hendrix, Nathaniel, Velásquez, Esther E, Pham, Harry, and Bazemore, Andrew W Topic(s) Role of Primary Care, Achieving Health System Goals, and What Family Physicians Do Keyword(s) Health Information Technology (HIT), Prime, and Quality Of Care Volume 34(10) Source Pharmacoepidemiology & Drug Safety Purpose Large telehealth companies and smaller aesthetic medicine providers used compounded semaglutide and tirzepatide to meet consumer demand for these drugs during their shortages. In this study, we estimate the documentation rate of compounded formulations of these drugs in the US primary care and characterize differences between users of compounded and brand-name formulations of these drugs. Methods We conducted a retrospective cohort study using data from the American Family Cohort, a nationwide US database of electronic health records from primary care practices, spanning January 1, 2021, to December 31, 2024. Patients with documented semaglutide and/or tirzepatide use were included. Brand-name drug prescriptions were identified from structured data; compounded formulation use was identified from clinical notes. Outcomes included the proportion of patients using compounded formulations and their characteristics. Results Among 153 044 included patients (64.0% female, mean age 55.0 years), 8.2% used compounded formulations, which made up an increasing share of semaglutide and tirzepatide use over time. Users of compounded formulations had longer mean therapy durations (compounded only: 10.0 months vs. brand-name only: 7.8 months) and were more likely to be female, non-Hispanic White, nondiabetic, and to live in areas of lower socioeconomic deprivation compared to patients who used only brand-name drugs. Conclusions Between January 2021 and December 2024, documentation of compounded semaglutide and tirzepatide use in US primary care settings appeared lower than surveys reporting that approximately 23% of patients using these medications received them from compounders. This suggests that many patients may access these medications outside of coordinated care. ABFM Research Read all 2024 Electronic Health Record Usability, Satisfaction, and Burnout for Family Physicians Go to Electronic Health Record Usability, Satisfaction, and Burnout for Family Physicians 2022 Variation in Scope and Area of Practice by Family Physician Race and Ethnicity Go to Variation in Scope and Area of Practice by Family Physician Race and Ethnicity 2026 Primary Care Physician Continuity Is a Consistent Measure Associated with Lower Costs and Hospitalizations Go to Primary Care Physician Continuity Is a Consistent Measure Associated with Lower Costs and Hospitalizations 2016 Access to Primary Care in US Counties Is Associated with Lower Obesity Rates Go to Access to Primary Care in US Counties Is Associated with Lower Obesity Rates
Author(s) Hendrix, Nathaniel, Velásquez, Esther E, Pham, Harry, and Bazemore, Andrew W Topic(s) Role of Primary Care, Achieving Health System Goals, and What Family Physicians Do Keyword(s) Health Information Technology (HIT), Prime, and Quality Of Care Volume 34(10) Source Pharmacoepidemiology & Drug Safety
ABFM Research Read all 2024 Electronic Health Record Usability, Satisfaction, and Burnout for Family Physicians Go to Electronic Health Record Usability, Satisfaction, and Burnout for Family Physicians 2022 Variation in Scope and Area of Practice by Family Physician Race and Ethnicity Go to Variation in Scope and Area of Practice by Family Physician Race and Ethnicity 2026 Primary Care Physician Continuity Is a Consistent Measure Associated with Lower Costs and Hospitalizations Go to Primary Care Physician Continuity Is a Consistent Measure Associated with Lower Costs and Hospitalizations 2016 Access to Primary Care in US Counties Is Associated with Lower Obesity Rates Go to Access to Primary Care in US Counties Is Associated with Lower Obesity Rates
2024 Electronic Health Record Usability, Satisfaction, and Burnout for Family Physicians Go to Electronic Health Record Usability, Satisfaction, and Burnout for Family Physicians
2022 Variation in Scope and Area of Practice by Family Physician Race and Ethnicity Go to Variation in Scope and Area of Practice by Family Physician Race and Ethnicity
2026 Primary Care Physician Continuity Is a Consistent Measure Associated with Lower Costs and Hospitalizations Go to Primary Care Physician Continuity Is a Consistent Measure Associated with Lower Costs and Hospitalizations
2016 Access to Primary Care in US Counties Is Associated with Lower Obesity Rates Go to Access to Primary Care in US Counties Is Associated with Lower Obesity Rates
